Journal: Epilepsia Open
Article Title: Intrinsic brain network stability during kainic acid‐induced epileptogenesis
doi: 10.1002/epi4.70002
Figure Lengend Snippet: Main networks (MNs) extracted by group ICA and averaged across all experimental trials. The ICA intensity (z‐map) ranged from 0 to 6.5 and represents the significant functional connectivity in each MN. All the MNs were overlaid on a co‐registered rat brain mask to aid structural identification. (A). Axial view of the selected MNs in the sham control rats of the frontal cortex network (FCN, including the orbital frontal and medial frontal cortex areas), hippocampal network (HPN, including the hippocampal and parahippocampal areas), thalamic network (THN, including the thalamus and hypothalamus areas), and the sensorimotor network (SMN, including primary and secondary motor cortex). (B). Similar MNs identified in the KA rats. (C). Unsupervised ROI extraction of the sub‐regions in RSFNs. The MNs (solid blue color) overlay to their sub‐regions as referred to in the rat brain atlas, where: C1. FCN overlays on cingulate cortex (green), prelimbic cortex (yellow), and retrosplenial cortex (red); C2. HPN overlays on dorsal (green) and ventral (yellow) hippocampus; C3. THN overlays on thalamus (green); and C4. SMN overlays on primary (yellow) and secondary (green) motor cortex. (D). The normalized area of coverage, which was computed by the percentage of the sub‐regions that were covered by the RSFNs. (E). Summary of all ROIs in the rat brain template.
Article Snippet: Group‐level BOLD‐fMRI data were analyzed using GICA in the Group ICA of FMRI Toolbox (GIFT) Matlab software to identify MNs during brain resting state.
Techniques: Functional Assay, Control, Extraction
